We do not know how much truth there is in the speculations about Manmadhan 2, but there it is all over the media about possible pairing up of Simbu and suchlike. The latest in the series is that Anushka will be paired up opposite Simbu for Manmadhan 2. It must be noted that it was Jyothika, who paired up with STR in Manmadhan. While no details about this development is official yet, if this happens it would be Anushka's second film with Simbhu - the first being Vaanam.
Earlier, it was rumored that TR has approached AR Rahman for tuning Manmadhan 2. There are no news on that front as yet and it's expected that an official announcement will be out soon.